GHS:SC starts out with you somehow ending up in a different dimension at the “Gregory House” hotel run by Gregory,who looks like a large mouse. He shows you your room, you fall asleep, and meet Death.
Death proposes a deal, in order to leave Gregorys House you must collect the souls of all the guests and give them to Death, only then you can return to the real world.

Sounds easy right? But in order to collect souls you must figure out each guests weaknesses, which can be quite challenging. Talking to guests and “peeping” are the only ways to figure out each weakness.
Items are collected along the game which often trigger certain reactions which leads to souls being collected.

After getting souls though often turns that guest against you, they will chase you when seen and make you participate in a “Horror Show” which is just them beating you up, you can be hurt outside a show, but the shows are the only places you cant run away from.

It plays out slighty like a blocky “Silent Hill” in a sense, the creepy hotel, item collecting, and strange charactors.

It has some problems though: it’s too short. If you know what to do, you can beat it in 2-3 hours. Not much replay value either which is too bad.

Overall it’s a very enjoyable,quirky game with a strange sense of humor and even stranger guests.

It’s a very rare find so good luck to you!!

There also a anime about called “Gregory Horror Show” but it revolves mainly around the guests.

Source: http://rr.ps2.ign.com/rrview/ps2/gregory_horror_show_soul_collector/498316/94888/